I had that too, actually in the very same game as Moniz getting hurt. The CPU decided it didn't like the way things were going down and broke off a 99 yard touchdown run after I pinned them deep. It was INTO a blitz, he broke a tackle, did a juke and somehow out ran everyone. Following drive, it was a long pass play where my defense suspiciously didn't react for about 2 seconds on a streak and the WR flew right by.
To that point in the game, they had been about 1-7 on 3rd down and only had 2 first downs total. Then two really quick TDs.
On the flip side, once I was up big and still throwing, again, because I'm Hawai'i and that's what we do... my throws started flying all over the place as if I took an accuracy penalty for scoring so many points, despite every single player on my offense being yellow and red on the coach view.
Shady things are going down in those types of games. I like to think that wouldn't be coded in the game, but knowing this game as I do, it wouldn't surprise me one bit.